NMES Therapy for Treatment of Muscle Atrophy

Clinical Evidence on CyMedica NMES

Klika AK, Yakubek G, Piuzzi N, Calabrese G, Barsoum WK, Higuera CA. Neuromuscular Electrical Stimulation Use after Total Knee Arthroplasty Improves Early Return to Function: A Randomized Trial [published online ahead of print, 2020 Jul 1]. J Knee Surg. 2020;10.1055/s-0040-1713420. doi:10.1055/s-0040-1713420

Sultan AA, Samuel LT, Bhave A. Utilization and outcomes of neuromuscular electric stimulation in patients with knee osteoarthritis: a retrospective analysis. Ann Transl Med. 2019;7(Suppl 7):S246. doi:10.21037/atm.2019.08.24

Delanois R, Sodhi N, Acuna A, Doll K, Mont MA, Bhave A. Use of home neuromuscular electrical stimulation in the first 6 weeks improves function and reduces pain after primary total knee arthroplasty: a matched comparison. Ann Transl Med. 2019;7(Suppl 7):S254. doi:10.21037/atm.2019.09.150

Poster Presentation: Bhave, A. Use of home Neuromuscular Electrical Stimulation (NMES) in first 6 weeks improves function and reduces pain after Primary Total Knee Arthroplasty.

Chughtai M, Piuzzi N, Yakubek G, et al. Use of an App-Controlled Neuromuscular Electrical Stimulation System for Improved Self-Management of Knee Conditions and Reduced Costs. Surg Technol Int. 2017;31:221‐226.

Pal S, Chughtai M, Sultan AA, et al. Impact of Neuromuscular Electrical Stimulation (NMES) on 90-Day Episode Costs and Post-Acute Care Utilization in Total Knee Replacement Patients with Disuse Atrophy. Surg Technol Int. 2017;31:384‐388.

Clinical Evidence for NMES Use in TKA Rehabilitation

Stevens-Lapsley JE, Balter JE, Wolfe P, Eckhoff DG, Kohrt WM. Early Neuromuscular Electrical Stimulation to Improve Quadriceps Muscle Strength After Total Knee Arthroplasty: A Randomized Controlled Trial. Phys Ther. 2012; 92:210-226

Stevens-Lapsley JE, Balter JE, Wolfe P, Eckhoff DG, Schwartz RS, Schenkman M, Kohrt WM. Relationship Between Intensity of Quadriceps Muscle Neuromuscular Electrical Stimulation and Strength Recovery After Total Knee Arthroplasty. Phys Ther. 2012; 92:1187-1196

A.J. Kittelson AJ, Stackhouse SK, Stevens-Lapsley JE. Neuromuscular Electrical Stimulation after TKA: A critical review of recent controlled studies. Eur J Physical & Rehab Medicine. 2013; 49(6):909-20

Levine M, McELroy K, Stakich V,Cicco J. Comparing Conventional Physical Therapy Rehabilitation With Neuromuscular Electrical Stimulation After TKA. Orthopedics. 2013; 36(3):319-24

Walls RJ, McHugh G, O’Gorman DJ, Moyna NM, O’Byrne JM. Effects Of Preoperative Neuromuscular Electrical Stimulation On Quadriceps Strength And Functional Recovery In Total Knee Arthroplasty. A Pilot Study. BMC Musculoskeletal Disorders. 2010; 11:119

Avramidis K, Karachalios T, Popotonasios K, Sacorafas D, Papathanasiades AA, Malizos KN. Does Electric Stimulation Of The Vastus Medialis Muscle Influence Rehabilitation After Total Knee Replacement? Orthopedics. 2011; 34:175

Mizner RL, Petterson SC, Stevens JE, Vandenborne K, Snyder-Mackler L. Early quadriceps strength loss after total knee arthroplasty. The contributions of muscle atrophy and failure of voluntary muscle activation. J Bone Joint Surg Am. 2005;87(5):1047‐1053. doi:10.2106/JBJS.D.01992

Thomas AC, Stevens-Lapsley JE. Importance of attenuating quadriceps activation deficits after total knee arthroplasty. Exerc Sport Sci Rev. 2012;40(2):95‐101. doi:10.1097/JES.0b013e31824a732b

Meier W, Mizner RL, Marcus RL, Dibble LE, Peters C, Lastayo PC. Total knee arthroplasty: muscle impairments, functional limitations, and recommended rehabilitation approaches. J Orthop Sports Phys Ther. 2008;38(5):246‐256. doi:10.2519/jospt.2008.2715

Clinical Evidence for NMES Use in ACLR Rehabilitation

Feil S, Newell J, Minogue C, Paessler HH. The effectiveness of supplementing a standard rehabilitation program with superimposed neuromuscular electrical stimulation after anterior cruciate ligament reconstruction: a prospective, randomized, single-blind study. Am J Sports Med. 2011;39:1238–1247

Snyder-Mackler L, Ladin Z, Schepsis A, Young J. Electrical stimulation of the thigh muscles after reconstruction of the anterior cruciate ligament: effects of electrically elicited contraction of the quadriceps femoris and hamstring muscles on gait and on strength of the thigh muscles. J Bone Joint Surg Am.1991;73(7):1025–1036

Snyder-Mackler L, Delitto A, Bailey SL, Stralka SW. Strength of the quadriceps femoris muscle and functional recovery after reconstruction of the anterior cruciate ligament. A prospective, randomized clinical trial of electrical stimulation. J Bone Joint Surg Am. 1995;77(8):1166‐1173. doi:10.2106/00004623-199508000-00004

Kim KM, Croy T, Hertel J, Saliba S. Effects of neuromuscular electrical stimulation after anterior cruciate ligament reconstruction on quadriceps strength, function, and patient-oriented outcomes: a systematic review. J Orthop Sports Phys Ther. 2010;40(7):383‐391. doi:10.2519/jospt.2010.3184

May Arna Risberg, Michael Lewek, Lynn Snyder-Mackler, A systematic review of evidence for anterior cruciate ligament rehabilitation: how much and what type? Physical Therapy in Sport 5 (2004) 125–145

Clinical Evidence for Muscle Weakness and NMES Use in Knee Osteoarthritis Patients

Vaz MA, Baroni BM, Geremia JM, et al. Neuromuscular electrical stimulation (NMES) reduces structural and functional losses of quadriceps muscle and improves health status in patients with knee osteoarthritis. J Orthop Res. 2013;31(4):511‐516. doi:10.1002/jor.22264

Alnahdi AH, Zeni JA, Snyder-Mackler L. Muscle impairments in patients with knee osteoarthritis. Sports Health. 2012;4(4):284‐292. doi:10.1177/1941738112445726

Lewek MD, Rudolph KS, Snyder-Mackler L. Quadriceps femoris muscle weakness and activation failure in patients with symptomatic knee osteoarthritis. J Orthop Res. 2004;22(1):110‐115. doi:10.1016/S0736-0266(03)00154-2

Petterson SC, Barrance P, Buchanan T, Binder-Macleod S, Snyder-Mackler L. Mechanisms underlying quadriceps weakness in knee osteoarthritis. Med Sci Sports Exerc. 2008;40(3):422‐427. doi:10.1249/MSS.0b013e31815ef285

Anwer S, Alghadir A. Effect of isometric quadriceps exercise on muscle strength, pain, and function in patients with knee osteoarthritis: a randomized controlled study. J Phys Ther Sci. 2014;26(5):745‐748. doi:10.1589/jpts.26.745

Fitzgerald GK, Piva SR, Irrgang JJ, Bouzubar F, Starz TW. Quadriceps activation failure as a moderator of the relationship between quadriceps strength and physical function in individuals with knee osteoarthritis. Arthritis Rheum. 2004;51(1):40‐48. doi:10.1002/art.20084

Imoto AM, Peccin MS, Teixeira LE, Silva KN, Abrahão M, Trevisani VF. Is neuromuscular electrical stimulation effective for improving pain, function and activities of daily living of knee osteoarthritis patients? A randomized clinical trial. Sao Paulo Med J. 2013;131(2):80‐87. doi:10.1590/s1516-31802013000100017

Bruce-Brand RA, Walls RJ, Ong JC, Emerson BS, O’Byrne JM, Moyna NM. Effects of home-based resistance training and neuromuscular electrical stimulation in knee osteoarthritis: a randomized controlled trial. BMC Musculoskelet Disord. 2012;13:118. Published 2012 Jul 3. doi:10.1186/1471-2474-13-118

Clinical Evidence for Muscle Atrophy and Rehabilitation Economic Impact

Chen SY, Wu N, Lee YC, Zhao Y. Association between muscle atrophy/weakness and health care costs and utilization among patients receiving total knee replacement surgery: a retrospective cohort study. J Pain Res. 2013;6:595‐603. Published 2013 Aug 1. doi:10.2147/JPR.S48235

Snow R,Granata J, Ruhil AV, Vogel K, McShane M, Wasielewski R. Associations between preoperative physical therapy and post-acute care utilization patterns and cost in total joint replacement. J Bone Joint Surg Am. 2014; 96(19), e165.